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TARGET SELECTION A Wild type Inner ear primordium BDNF NT-3 B TrkB, TrkC double mutant BDNF NT-3 C BDNF replaces NT-3 BDNF BDNF Mature inner ear Vestibular primordium Cochlear primordium Semi- circular canals Cochlea Semi- circular canals Cochlea Semi- circular canals Cochlea No innervation Too much cochlear innervation FIGURE 6.
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5 kcalmol and a r2 of 0. Biochim. 06° ] CHAPTER 13 Minor Trace Minerals TOXICITY OF COPPER 263 Copper toxicity is rare. Apoptosis (from Greek: apo from, pto- sis falling, earlier the term programed cell necrosis was used) normal (programed) cells death (cells suicide) [343, 808, 1097] differs from necrosis (accidental, traumatic cells death as a result of the physical or chemical action) by the morphological features (such as the membrane deformation in the first case and loss of its integrity in the second) and by the character of the biochemical reactions (e.
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