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(1983), Journal of Pharmacology and Experimental Therapeutics, 224, 64753. Fig. A number of factors in the real world differ from the ideal conditions used to construct a model. Radiology 1997;204:677684.

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CHAPTER 50 THYROID DISORDERS 461 Geneprotein Disease Pathophysiology Molecular defect Inheritance Chromosome TRH TRH-receptor TSH Hypothalamic hypopituitarism TSH-deficient hypothyroidism TSH-deficient hypothyroidism TSH-secreting adenomashyperthyroidism Combined pituitary hormone Isolated TRH deficiency Unresponsiveness brian dolan forex TRH TSH-βsubunit mutation, bioinactive TSH Oversecretion of TSH, molecular defect Unknown Inactivating mutations Mutations in β chain Unknown AR 3 Pit-1 TSH-receptor unknown Abnormal pituitary development; Mutation in Pit-1 gene Activating mutation AD, AR 3p11 Gsα (α-subunit of stimulatory G protein) hyperthyrotropinemia Toxic adenoma McCune-Albright syndrome Pseudohypoparathyroidism Ia Activation of cAMP cascade: enhancement of growthfunction Sporadic Sporadic (mosaicism) AD 20q.

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